Letrozole Sustained Release Tablets

Litz 5 SR contains Letrozole, a third-generation non-steroidal aromatase inhibitor used primarily for ovulation induction in women with anovulatory infertility, particularly in Polycystic Ovary Syndrome (PCOS). It works by lowering estrogen levels, which stimulates the pituitary gland to release more follicle-stimulating hormone (FSH), promoting follicular development and ovulation.

Therapeutic Class:

Aromatase Inhibitor – Ovulation Induction / Hormone Modulation Agent

Indications:

• Ovulation induction in women with PCOS
• Female infertility due to anovulation
• Adjunct in assisted reproductive techniques (ART)
• Hormone-sensitive breast cancer in postmenopausal women (as per physician discretion)

Mechanism of Action:

Letrozole inhibits the enzyme aromatase, responsible for the conversion of androgens to estrogens. By reducing estrogen levels, it triggers a rise in GnRH, FSH, and LH, leading to ovarian follicular growth and ovulation.

Dosage & Administration:

• For ovulation induction:
  • 5 mg to 5 mg orally once daily for 5 days
  • Usually started on Day 2, 3, or 5 of the menstrual cycle
  • Maximum of 3–6 cycles recommended
  • Dosing under supervision of a fertility specialist or gynecologist
• For breast cancer (postmenopausal):
  • As per oncologist’s guidance, typically 2.5 mg daily

Available Strengths:

• Litz 5 SR – Letrozole 5 mg Sustained Release Tablets

Common Side Effects:

• Headache
• Hot flashes
• Dizziness
• Fatigue
• Nausea
• Abdominal cramps
• Back pain
• Breast tenderness
• Mood swings

Storage:

Store at a temperature below 25°C. Keep in a dry place away from sunlight and children.